The 1901 Michigan Agricultural Aggies football team represented Michigan Agricultural College (MAC)—now known as Michigan State University—as a member of the Michigan Intercollegiate Athletic Association (MIAA) during the 1901 college football season. In their first year under head coach George Denman, the Aggies compiled am overall record of 3–4–1 record with a mark of and 3–3–1 in conference play, and outscored opponents by a total of 120 to 94. The team played home games at College Field in East Lansing, Michigan.
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